Dahmane (Fo Series)

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The strikes this week had caused logjams on city streets and at airports, as hundreds of cabbies protested over competition from minicabs. The government gave in to one of their demands on Thursday, agreeing it would not register new minicabs while a mediator spends two months trying to resolve the crisis. Taxi unions said they were ending strike action, with Nordine Dahmane of the FO-Taxis union hailing the government's "brave and wise decision". Taxi drivers had threatened "indefinite" strikes after blocking city streets and access to pick-up spots at airports.

The minicabs, known in France as tourist vehicles with chauffeur VTCs , were introduced in as an attempt to address the chronic shortfalls of taxis, particularly in Paris, the most visited city in the world. Unlike regular taxis, they must be booked in advance and do not have the right to pick up passengers who hail them in the street. The majority of phenolic acids were present in the bound form. Using a Q-OT-MS, 22 compounds were tentatively identified, 16 of which were identified for the first time in hazelnut samples. The newly identified compounds consisted of flavonoids, phenolic acids and related compounds, hydrolysable tannins and related compounds, and other phenolics.

Three antioxidant assays demonstrated similar trends that roasted hazelnut skin rendered the highest activity. The present work suggests that roasted hazelnut skin is a rich source of phenolics and can be considered as a value-added co-product for use as functional food ingredient and antioxidant. Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid. The topical application of the cosmeto-textile provides a reservoir effect in the skin delivery of GA. The close contact of the cosmeto-textile, containing microsphere-encapsulated GA ME-GA , with the skin and their corresponding occlusion, may be the main reasons that explain the crossing of active principle GA through the skin barrier, located in the stratum corneum, and its penetration into the different compartments of the skin , epidermis and dermis.

The test is based on a non-invasive ex vivo methodology that evaluates lipid peroxides formed in the outermost layers of the SC from human volunteers after UV radiation to determine the effectiveness of an antioxidant. This methodology may be used as a quality control tool to determine ex vivo the percentage of LPO inhibition on human SC for a variety of antioxidants that are topically applied, in this case GA.

Results show that LPO formation was inhibited in human SC when GA was applied directly or embedded in the cosmeto-textile, demonstrating the effectiveness of both applications. This methodology could be used to determine the effectiveness of topically applied antioxidants encapsulated in cosmeto-textiles on human SC. Improvement of polyphenol properties upon glucosylation in a UV-induced skin cell ageing model. Polyphenols are strong antioxidant molecules allowing prevention of skin photo-ageing damages, but their use is limited due to low solubility and toxicity towards skin cells.

We postulated that enzymatic glucosylation could improve their solubility, stability and, consequently, their efficacy. The aim of this work was to study changes induced by addition of a glucose moiety on two polyphenols displaying very different chemical structures [caffeic acid CA , epigallocatechingallate EGCG and there glucosylated form, Glc-CA and Glc-EGCG] by assessing their cytotoxic properties and their antioxidant and anti-inflammatory activities.

Their antioxidant effect was assessed first by the classical DPPH radical-scavenging method. Then, a panel of human skin cells keratinocytes, melanocytes, fibroblasts and endothelial cells was used to evaluate their effect on cell toxicity and their antioxidant activities. With this aim, a photo-ageing model based on UV irradiation of skin cells was established.


Glucosylated derivatives did not display more toxic effect on various skin cells. Moreover, toxicity was even strongly reduced for caffeic acid upon glucosylation. EGCG, on keratinocytes. Both glucosyl-polyphenols display the same activity as their parent molecule in decreasing inflammatory factor production. Our results. They are powerful antioxidants and thought to act as scavengers for free radicals and single oxygen that are formed by excessive exposure of skin to sunlight.

However the role of the particular representatives of the carotenoid antioxidants family in the skin defense mechanism is still unclear and has to be clarified. Analyzing Raman signals originating from the carbon-carbon double bond stretch vibrations of the molecules under blue and green laser excitation we were able to characterize quantitativly the concentrations of each carotenoid in alive human skin. This novel technique allows the quantitative assessment of individual carotenoid species in the skin rather then the cumulative level of long-chain carotenoids mixture as we could measure in our previous works.

The required laser light exposure levels are well within safety standards. This technique holds promise as a method of rapid screening of carotenoids composition of human skin in large populations and suitable in clinical studies for assessing the risk for cutaneous diseases. The complication of asthma during pregnancy is associated with a number of poor outcomes for the mother and fetus. This may be partially driven by increased oxidative stress induced by the combination of asthma and pregnancy. Asthma is a chronic inflammatory disease of the airways associated with systemic inflammation and oxidative stress, which contributes to worsening asthma symptoms.

Pregnancy alone also intensifies oxidative stress through the systemic generation of excess reactive oxidative species ROS. Antioxidants combat the damaging effects of ROS; yet antioxidant defenses are reduced in asthma. Diet and nutrition have been postulated as potential factors to combat the damaging effects of asthma. In particular, dietary antioxidants may play a role in alleviating the heightened oxidative stress in asthma.

Although there are some observational and interventional studies that have shown protective effects of antioxidants in asthma, assessment of antioxidants in pregnancy are limited and there are no antioxidant intervention studies in asthmatic pregnancies on asthma outcomes. The aims of this paper are to i review the relationships between oxidative stress and dietary antioxidants in adults with asthma and asthma during pregnancy, and ii provide the rationale for which dietary management strategies, specifically increased dietary antioxidants , might positively impact maternal asthma outcomes.

Improving asthma control through a holistic antioxidant dietary approach might be valuable in reducing asthma exacerbations and improving asthma management during pregnancy, subsequently impacting perinatal health. Marine fish skin peptides FSP have been widely studied due to their antioxidant and antimicrobial properties. We aimed to use a natural antioxidant , FSP, to replacing synthetic preservatives in a pork patty model, which is safer for human body. Moreover, nano-liposome technology can be applied for masking the fishy smell and improving the stability of this peptide.

This effect in the patties depended on the FSP concentration.

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None of the physicochemical results showed remarkable changes except the pH and VBN values. Therefore, this study provides evidence that FSP has great potential to inhibit the lipid oxidation of pork patties and is capable of maintaining the quality and extending the shelf life. Influence of two different IR radiators on the antioxidative potential of the human skin. Resonance Raman spectroscopy was used for the fast in vivo detection of the concentration of carotenoid antioxidant substances such as beta-carotene and lycopene in human skin and for the measurement of their degradation dynamics, subsequent to infrared IR irradiation emitted by two different IR radiators applied at the same power density.

One of the radiators was equipped with a water filter in front of the radiation source WIRA and the other was a usual broadband system without a water filter standard IR radiator - SIR. Furthermore, all twelve volunteers who participated in the study felt that the irradiation with the SIR was disagreeably warmer on the skin surface compared to the WIRA, in spite of the same power density values for both radiators on the skin surface. Taking the previous investigations into consideration, which clearly showed production of free radicals in the skin subsequent to IR irradiation, it can be concluded that during the application of WIRA irradiation on the skin , fewer radicals are produced in comparison to the SIR.

Integrating spheres for improved skin photodynamic therapy. The prescribed radiant exposures for photodynamic therapy PDT of superficial skin cancers are chosen empirically to maximize the success of the treatment while minimizing adverse reactions for the majority of patients. They do not take into account the wide range of tissue optical properties for human skin , contributing to relatively low treatment success rates. Additionally, treatment times can be unnecessarily long for large treatment areas if the laser power is not sufficient.

Both of these concerns can be addressed by the incorporation of an integrating sphere into the irradiation apparatus. This improvement can be determined in advance of treatment by measuring the reflectance from the tissue through a side port on the integrating sphere, allowing for patient-specific treatment times. The sphere is also effective at improving beam flatness, and reducing the penumbra, creating a more uniform light field. The side port reflectance measurements are also related to the tissue transport albedo, enabling an approximation of the penetration depth, which is useful for real-time light dosimetry.

Investigations of antioxidant -mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin. Radioprotection and mitigation effects of the antioxidants , Eukarion EUK , curcumin, and the curcumin analogs D12 and D68, on radiation-induced DNA damage or lipid peroxidation in murine skin were investigated. These antioxidants were studied because they have been previously reported to protect or mitigate against radiation-induced skin reactions.

DNA damage was assessed using two different assays. None of the studied antioxidants showed significant mitigation of skin DNA damage induced by local irradiation. In contrast, all the studied antioxidants demonstrated significant mitigating and protecting effects on radiation-induced lipid peroxidation at one or more of the three time points after local skin irradiation. Our results show no evidence for mitigation of DNA damage by the antioxidants studied in contrast to mitigation of lipid peroxidation.

Since these agents have been reported to mitigate skin reactions following irradiation, the data suggest that changes in lipid peroxidation levels in skin may reflect developing skin reactions better than residual post-irradiation DNA damage in skin cells. Further direct comparison studies are required to confirm.

Nanoethosomal formulation of gammaoryzanol for skin -aging protection and wrinkle improvement : a histopathological study. Free radical scavengers and antioxidants , with the main focus on enhanced targeting to the skin layers, can provide protection against skin ageing. The aim of the present study was to prepare nanoethosomal formulation of gammaoryzanol GO , a water insoluble antioxidant , for its dermal delivery to prevent skin aging.

Nanoethosomal formulation was prepared by a modified ethanol injection method and characterized by using laser light scattering, scanning electronic microscope SEM and X-ray diffraction XRD techniques. Antioxidant activity of GO-loaded formulation was investigated in vitro using normal African green monkey kidney fibroblast cells Vero.

Furthermore, the effect of GO-loaded nanoethosomes on skin wrinkle improvement was studied by dermoscopic and histological examination on healthy humans and UV-irradiated rats, respectively. The optimized nanoethosomal formulation showed promising characteristics including narrow size distribution 0. The XRD results confirmed uniform drug dispersion in the nanoethosomes structure.

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In vitro and in vivo antioxidant studies confirmed the superior antioxidant effect of GO-loaded nanoethosomal formulation compared with control groups blank nanoethosomes and GO suspension. Nanoethosomes was a promising carrier for dermal delivery of GO and consequently had superior anti-aging effect. Skin injuries are common among neonatal intensive care unit NICU patients and may lead to significant complications. Standardized methods of preventing, detecting, and treating skin injuries are needed. The aim of this project was to standardize the assessment, documentation, and tracking of skin injuries among hospitalized neonatal patients and to determine the incidence of pressure ulcers in this patient population.

Interventions were implemented upon identification of a skin injury. After the initiation of skin rounds, the baseline incidence of pressure ulcers increased from 0. The most common skin injuries detected included erythema, skin tears, and ecchymosis; the most common cause of injuries was medical devices. A dedicated skin team can improve the detection and reporting of skin injuries among NICU patients. Determination of the incidence of pressure ulcers in this population is critical to develop targeted interventions.

Further research is needed to determine the most effective interventions to prevent and treat skin injuries among hospitalized neonates. We examined the effects of vitamin C in Pluronic F on diabetic wound healing. Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C antioxidant sol , Pluronic F, or Pluronic F plus vitamin C antioxidant sol-gel.

The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined. After 7 and 14 days of wound injury, the antioxidant sol-gel improved wound healing significantly by accelerated epidermal and dermal maturation, an increase in collagen content, and a decrease in apoptosis formation. However, the wounds of all treatments healed mostly at 3 weeks.

Vitamin C in Pluronic F hastened cutaneous wound healing by its antioxidant and antiapoptotic mechanisms through a good drug delivery system. This study showed that Pluronic F plus vitamin C could potentially be employed as a novel wound-healing enhancer. Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats. Topical ivermectin improves allergic skin inflammation.

Ivermectin IVM is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti-inflammatory properties. Here, we investigated the activity of IVM in a murine model of atopic dermatitis AD induced by repeated exposure to the allergen Dermatophagoides farinae, and in standard cellular immunological assays. Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen-specific T cells, as well as the production of inflammatory cytokines.

While IVM had no major impact on the functions of dendritic cells in vivo and in vitro, IVM impaired T-cell activation, proliferation, and cytokine production following polyclonal and antigen-specific stimulation. Altogether, our results show that IVM is endowed with topical anti-inflammatory properties that could have important applications for the treatment of T-cell-mediated skin inflammatory diseases. Skin delivery of epigallocatechingallate EGCG and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage.

The present work attempts to develop and statistically optimize transfersomes containing EGCG and hyaluronic acid to synergize the UV radiation-protective ability of both compounds, along with imparting antioxidant and anti-aging effects. Transfersomes were prepared by thin film hydration technique, using soy phosphatidylcholine and sodium cholate, combined with high-pressure homogenization.

The composition of the transfersomes was statistically optimized by Design of Experiments using Box-Behnken design with four factors at three levels. The optimized transfersome formulation showed vesicle size, polydispersity index and zeta potential of Effect of Alpinia zerumbet components on antioxidant and skin diseases-related enzymes. Background The skin is chronically exposed to endogenous and environmental pro-oxidant agents, leading to the harmful generation of reactive oxygen species.

Antioxidant is vital substances which possess the ability to protect the body from damage cause by free radicals induce oxidative stress. Alpinia zerumbet, a traditionally important economic plant in Okinawa, contains several interesting bioactive constituents and possesses health promoting properties. In this regard, we carried out to test the inhibitory effect of crude extracts and isolated compounds from A. Collagenase, elastase, hyaluronidase and tyrosinase were designed for enzymatic activities to investigate the inhibitory properties of test samples using a continuous spectrophotometric assay.

The inhibitory capacity of test samples was presented at half maximal inhibitory concentration IC Results The results showed that aqueous extract of the rhizome was found to have greater inhibitory effects than the others on both of antioxidant and skin diseases-related enzymes. Furthermore, 5,6-dehydrokawain DK , dihydro-5,6-dehydrokawain DDK and 8 17 ,labdadiene,dial labdadiene , isolated from rhizome, were tested for antioxidant and enzyme inhibitions. Conclusion Our results indicate that the rhizome aqueous extract proved to be the source of bioactive compounds against enzymes responsible for causing skin diseases.

Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Background Oxidative stress has been identified in the peritoneal fluid and peripheral blood of women with endometriosis. However, there is little information on the antioxidant intake for this group of women. The objectives of this work were 1 to compare the antioxidant intake among women with and without endometriosis and 2 to design and apply a high antioxidant diet to evaluate its capacity to reduce oxidative stress markers and improve antioxidant markers in the peripheral blood of women with endometriosis.

Oxidative stress and antioxidant markers vitamins and antioxidant enzymatic activity were determined in plasma every month. Results Comparison of antioxidant intake between WWE and WEN showed a lower intake of vitamins A, C, E, zinc, and copper by WEN p antioxidant enzyme activity superoxide dismutase and glutathione peroxidase as well as a decrease in oxidative stress markers malondialdehyde and lipid hydroperoxides were observed in the HAD group after two months of intervention. These phenomena were not observed in the control group. Conclusion WEN had a lower. Investigation of jumbo squid Dosidicus gigas skin gelatin peptides for their in vitro antioxidant effects.

Peptides derived from tryptic hydrolysate of jumbo squid Dosidicus gigas skin gelatin were assessed for their antioxidant properties in different in vitro assay systems. The hydrolysate itself exhibited a strong lipid peroxidation inhibition and it was much higher than that of natural antioxidant , alpha-tocopherol. In addition, it could scavenge highly active free radicals in oxidative systems, in the order of hydroxyl and carbon-centered radicals. Furthermore, viability of radical-mediated oxidation-induced human lung fibroblasts was enhanced following the treatment of two peptides.

However it did not exhibit substantial ion chelation, and we presumed that the observed radical scavenging potency of these peptides play a vital role for their strong antioxidant activity. Based on our results we suggest that hydrophobic amino acids present in peptide sequences contributed greatly for observed antioxidant activities. Introduction Delayed posthypoxic leukoencephalopathy DPHL may result from a variety of hypoxic insults, including respiratory depression from an opiate overdose.

The underlying pathophysiological mechanism of DPHL remains uncertain. We describe a patient with a typical case of DPHL who responded clinically to antioxidant treatment. Methods Clinical, serological, and radiographic investigations were undertaken in the evaluation of the patient. Results A year-old man developed altered mental status 10 days following recovery from an opiate overdose and aspiration pneumonia that required intubation.

The clinical course and brain imaging were consistent with DPHL. Initiation of antioxidant therapy with vitamin E, vitamin C, B-complex vitamins, and coenzyme Q10 coincided with the prompt reversal of clinical deterioration. Conclusions The potential therapeutic effect of antioxidants on DPHL needs to be explored in future cases. If this relationship indeed holds true, it would be consistent with the hypothesis that formation of reactive oxygen species during reperfusion plays a role in the pathophysiology of this disorder.

Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice. Collagen hydrolysates CHs have been demonstrated to have positive effects on skin photoaging by topical application or oral ingestion. However, there has been little research on their influence on skin chronological aging. The color, luster and quantity of hair were obviously ameliorated. Moreover, the structure of epidermis and dermis, the density and distribution of collagen fibers and the ratio of type I to type III collagen were improved in a dose-dependent manner as shown by histochemical staining.

Oral ingestion of CHs increased the collagen content and antioxidant enzyme activities and improved the appearance and structure of skin. These results suggest the potential of CHs as an anti- skin -aging ingredient in nutraceuticals or functional foods. Characterisation of Mediterranean grape pomace seed and skin extracts: polyphenolic content and antioxidant activity. As expected, seed pomace extracts contained higher amounts of polyphenols then skin pomace extracts. Indeed, seeds from Syrah contained a particularly important amount of total polyphenols and tannins in both type of extract up to These extracts also expressed the highest antioxidant potential with every test.

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For skins , the maximum total phenolic was found in Alicante EAQ Results obtained in this article constitute a useful tool for the pre-selection of grape pomace seed and skin extracts for nutraceutical purposes. Purification and characterization of novel antioxidant peptides from enzymatic hydrolysates of tilapia Oreochromis niloticus skin gelatin.

To obtain hydrolysates with high degree of hydrolysis DH and scavenging radical activity, tilapia skin gelatin TSG was hydrolyzed by properase E and multifect neutral. The optimum hydrolysis condition of each enzyme was determined using the orthogonal experiment, and double-enzyme hydrolysis was further applied. The results showed the tilapia skin gelatin hydrolysate TSGH obtained by progressive hydrolysis using multifect neutral and properase E had the highest DH and hydroxyl radical scavenging activity.

Finally, two antioxidant peptides were identified and the amino acid sequences were Glu-Gly-Leu The IC 50 values of two peptides on hydroxyl radical scavenging activities were 4. Therefore, the results demonstrated that the hydrolysates of TSG prepared by multifect neutral and properase E could serve as a source of peptides with high antioxidant activity. It provided a scientific basis for the preparation of antioxidant peptides. Antioxidants in Asian-Korean and caucasian skin : the influence of nutrition and stress. The antioxidant status of the human skin provides protection against the destructive action of free radicals.

Most antioxidants cannot be synthesized by the human organism itself, but have to be ingested with a healthy nutrition rich in fruit and vegetables. The Korean cuisine is known to be one of the healthiest worldwide. This binational study investigated the cutaneous carotenoid concentrations in German subjects, South Korean subjects and immigrant Korean subjects resident in Germany and examined whether dietary- and lifestyle-related differences are reflected in the cutaneous carotenoid concentrations.

Measurements of the carotenoid concentrations of healthy volunteers were performed using a non-invasive spectroscopic measurement system based on reflectance spectroscopy. In the present study South Korean residents showed a significantly higher antioxidant status than both native German residents and Korean immigrants living in Germany p antioxidant status unless the stress exposure can be reduced simultaneously.

Karger AG, Basel. Oxybenzone oxidation following solar irradiation of skin : photoprotection versus antioxidant inactivation. We used noninvasive Fourier transform FT Raman spectroscopy to follow the fate of the broadly used ultraviolet UVA sun blocker, oxybenzone, after topical application to the skin. Our results showed that oxybenzone is rapidly photo-oxidized, yielding oxybenzone semiquinone, a potent electrophile, which reacts with thiol groups on important anti-oxidant enzymes and substrates, such as thioredoxin reductase and reduced glutathione, respectively.

Although oxybenzone is an excellent broad spectrum UVA filter, its rapid oxidation followed by the inactivation of important antioxidant systems indicates that this substance may be rather harmful to the homeostasis of the epidermis. Furthermore, these results demonstrate that FT-Raman spectroscopy is a useful method for studying the transport and metabolism of active ingredients in topical preparations.

In this work, one of Zingiber officinale components, shogaol, was tested with 1,1-diphenylpicrylhydrazyl DPPH radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. In the in vitro wound healing assay for 12 or 24 h, with shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent. Arginine glutamate improves healing of radiation-induced skin ulcers in guinea pigs.

The increase in the incidence of the radiation-induced skin injury cases and the absence of standard treatments escalate the interest in finding new and effective drugs for these lesions. Radiation skin injury was produced on the thigh of guinea pigs by 60 Gy local X-ray irradiation. Treatment was started 6 weeks after the irradiation when ulcers had been formed. Arginine glutamate was administered by subcutaneous injections around the wound edge. Methyluracil was chosen as the comparison drug.

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The animals were sacrificed on day 21 after the start of treatment and the irradiated skin tissues were subjected to histological evaluation, cytokines analysis, lipid peroxidation and antioxidant enzymes analysis. We have shown that arginine glutamate significantly p antioxidant enzymes activity and promoted cell proliferation as well as collagen synthesis.

These results demonstrate that arginine glutamate successfully improves the healing of radiation-induced skin ulcers. In all probability, the curative effect is associated with the interaction of arginine with nitric oxide synthase II and arginase I, but further investigations are needed to validate this. Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin.

Resveratrol is an effective anti-aging molecule with diverse biologic activity. It functions as a dual antioxidant that can neutralize free radicals and increase intrinsic antioxidant capacity. Additionally resveratrol increases mitochondrial biogenesis and has anti-inflammatory, anti-diabetic, and anti-cancer activity.

This stabilized high concentration formulation demonstrates percutaneous absorption and alterations in gene expression such as hemoxygenase-1 HO-1 , vascular endothelial growth factor VEGFA , and collagen 3 COL3A1. Clinical assessment showed a statistically significant improvement in fine lines and wrinkles, skin firmness, skin elasticity, skin laxity, hyperpigmentation, radiance, and skin roughness over baseline in 12 weeks.

Ultrasound measurements in the periorbital area showed an average improvement of These studies confirm that topical resveratrol, baicalin, and vitamin E are valuable ingredient that can be used for skin rejuvenation. An implementation algorithm to improve skin-to-skin practice in the first hour after birth. Evidence supporting the practice of skin-to-skin contact and breastfeeding soon after birth points to physiologic, social, and psychological benefits for both mother and baby. While in immediate, continuous, uninterrupted skin-to-skin contact with mother in the first hour after birth, babies progress through 9 instinctive, complex, distinct, and observable stages including self-attachment and suckling.

However, the most recent Cochrane review of early skin-to-skin contact cites inconsistencies in the practice; the authors found "inadequate evidence with respect to details … such as timing of initiation and dose. Using data from vaginal births in Japan and caesarean births in Australia, the algorithm utilizes data in a new way to highlight challenges to best practice. The use of a tool to analyse the implementation of skin-to-skin care in the first hour after birth illuminates the successes, barriers, and opportunities for improvement to achieving the standard of care for babies.

Future application should involve more diverse facilities and Robson's classifications. Production of antioxidant compounds of grape seed skin by fermentation and its optimization using response surface method. Skins and seeds of grape are waste generated from food industry. These wastes contain nutrients of which able to be utilized as an important source for antioxidant metabolite production. Through an environmentally friendly process, natural antioxidant material was produced.

This study aimed to generate antioxidant compounds by liquid fermentation. Optimization was carried out by using Schizosaccharomyces cerevisiae in Katu leaf substrate. Optimization variables through response surface methodology RSM were of sucrose concentration, skins and seeds of grape concentration, and pH. The resulted antioxidant activity was of 1.

Mathematical model of variance analysis using a second order polynomial corresponding to the resulted data for the antioxidant was of From the gained equation, the optimum yield from all variables was significant. A regional programme to improve skin cancer management. In , public specialist and general practice services in Canterbury were unable to manage demand for skin cancer treatment.

Local clinicians decided the solution was to develop a see-and-treat skin excision clinic staffed by plastic surgeons and general practitioners GPs , and the introduction of subsidised excisions in general practice. This paper describes the collaboration between clinicians, managers and funders and the results and quality management measures of these initiatives. There is an increasing incidence of skin cancer.

GPs in Canterbury were unable to meet increasing demand for skin cancer treatment because some lacked confidence and competence in skin cancer management. There was no public funding for primary care management of skin cancer, driving patients to fully funded secondary care services. Secondary care services were at capacity, with no coordinated programme across primary and secondary care.

The programme has resulted in a greater number of skin cancers being treated by the public health system, a reduction in waiting times for treatment, and fewer minor skin lesions being referred to secondary care. Quality measures have been achieved and are improving steadily. Development of the programme has improved working relationships between primary and secondary care clinicians. The strategy was to facilitate the working relationship between primary and secondary care and increase the capacity for skin lesion excisions in both sectors. Skin cancer management can be improved by a coordinated approach between primary and secondary care.

Recently, development and research of nutraceuticals based on marine collagen peptides MCPs have been growing due to their high homology with human collagens, safety, bioavailability through gut, and numerous bioactivities. The major concern regarding safety of MCPs intake relates to increased risk of oxidative stress connected with collagen synthesis likewise in fibrosis and to ROS production by MCPs-stimulated phagocytes.

The supplementation remarkably improved skin elasticity, sebum production, and dermal ultrasonic markers. Metabolic data showed significant increase of plasma hydroxyproline and ATP storage in erythrocytes. A combination of MCPs with skin -targeting AOs could be effective and safe supplement to improve skin properties without risk of oxidative damage.

Inhibition of advanced glycation end products by red grape skin extract and its antioxidant activity. The objective of the present study was to determine the phytochemical content and the protective effect of red grape skin extract RGSE against fructose-mediated protein oxidation. In addition, RGSE was screened for its potential as an antioxidant using various in vitro models.

Antioxidant activity was measured by 2,2-diphenylpicrylhydrazyl DPPH , hydroxyl radical scavenging activity, superoxide radical scavenging activity, trolox equivalent antioxidant capacity, ferric reducing antioxidant power FRAP , ferrous ion chelating power. The total phenols content was measured by Folin-Ciocalteu assay, the flavonoids content by the AlCl3 colorimetric method.

The protein oxidation was examined using the level of protein carbonyl content and thiol group. The results showed that the content of total phenolics, flavonoids and total anthocyanins in RGSE was In addition, RGSE had trolox equivalent antioxidant capacity assay The results showed that RGSE at different concentrations 0. The RGSE markedly decreased the level of fructosamine, which is directly. Antifungal and antioxidant activities of Coleonema album and C. Coleonema album Thunb Bart. Wendl Rutaceae has been used in the formulation of skincare products, and the Khoisan people rub it on their skin to add luster.

Coleonema pulchellum I. Williams has received less attention in the South African traditional medicine. This study investigates the antifungal and antioxidant activities of C. Antifungal activity of leaf extracts was determined using the microdilution method with griseofulvin and ketoconazole as controls. Antifungal capacity of EO was investigated using the 'Volatile release plate method'. The incubation time was seven days. Antioxidant activities of the leaf extracts were determined.

Methanol leaf extract of C. Terpenes formed the major components of the EO. The EO from both plants inhibited the growth of T. This study revealed the therapeutic value of C. Coleonema album and C. Antioxidant , immunomodulatory and antiproliferative effects of gelatin hydrolysate from unicorn leatherjacket skin. The in vitro cellular bioactivities including, antioxidant , immunomodulatory and antiproliferative effects of a gelatin hydrolysate GH prepared from unicorn leatherjacket skin , using partially purified glycyl endopeptidase, were investigated in order to optimize the use of fish skin waste products as functional food ingredients.

GH also protected against the H2 O2 -induced reduction in cellular antioxidant enzyme activities, superoxide dismutase and catalase, in HepG2 cells.

Cell proliferation in human colon cancer Caco-2 cells was significantly reduced in a dose-dependent manner following incubation with GH. These results indicate that GH has several bioactivities which support its potential as a promising functional food ingredient with various health benefits. Cu-Zn superoxide dismutase Sod1 loss causes a redox imbalance as it leads to excess superoxide generation, which results in the appearance of various aging-related phenotypes, including skin atrophy.

Noble metal nanoparticles, such as palladium Pd and platinum Pt nanoparticles, are considered to function as antioxidants due to their strong catalytic activity. In the present study, we investigated the protective effects of PAPLAL against aging-related skin pathologies in mice. Pt nanoparticles exhibited marked SOD and catalase activity, while Pd nanoparticles only displayed weak SOD and catalase activity in vitro.

Although the SOD and catalase activity of the Pt nanoparticles significantly declined after they had been oxidized in air, a mixture of Pd and Pt nanoparticles continued to exhibit SOD and catalase activity after oxidation. Importantly, a mixture of Pd and Pt nanoparticles with a molar ratio of 3 or 4 to 1 continued to exhibit SOD and catalase activity after oxidation, indicating that Pd nanoparticles prevent the oxidative deterioration of Pt nanoparticles. PAPLAL is a potentially powerful tool for the treatment of aging-related skin diseases caused by oxidative damage.

Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice. Skin cell protection against UVA by Sideroxyl, a new antioxidant complementary to sunscreens. Oxidative stress resulting from photosensitized ROS production in skin is widely accepted as the main contributor to the deleterious effects of UVA exposure. Among the mechanisms known to be involved in UVA-induced oxidative damage, iron plays a central role. UVA radiation of skin cells induces an immediate release of iron, which can then act as a catalyst for uncontrolled oxidation reactions of cell components.

Such site-specific damage can scarcely be counteracted by classical antioxidants. In contrast, iron chelators potentially offer an effective way to protect skin against UVA insults. However, iron chelation is very difficult to achieve without disturbing iron homeostasis or inducing iron depletion. A novel compound was developed to avoid these potentially harmful side effects. Sideroxyl was designed to acquire its strong chelating capability only during oxidative stress according to an original process of intramolecular hydroxylation.

Herein, we describe in vitro results demonstrating the protective efficiency of Sideroxyl against deleterious effects of UVA at the molecular, cellular, and tissular levels. First, the Sideroxyl diacid form protects a model protein against UVA-induced photosensitized carbonylation. Second, intracellular ROS are dose-dependently decreased in the presence of Sideroxyl in both human cultured fibroblasts and human keratinocytes. Finally, Sideroxyl provides protection against UVA-induced alterations in human reconstructed skin. These results suggest that Sideroxyl may prevent UVA-induced damage in human skin as a complement to sunscreens, especially in the long-wavelength UVA range.

Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality. Skin aging can largely be attributed to dermal fibroblast dysfunction and a decrease in their biosynthetic activity. Regardless of the underlying causes, aging fibroblasts begin to produce elements of the extracellular matrix in amounts that are insufficient to maintain the youthful appearance of skin. The goal of mesopreparations is primarily to slow down and correct changes in skin due to aging. The rationale for developing complex polycomponent mesopreparations is based on the principle that aging skin needs to be supplied with the various substrates that are key to the adequate functioning of the fibroblast.

In vitro experiments suggest that there is a significant increase in the synthetic and prophylactic activity of fibroblasts with treated NCTF, and a significant increase in the ability of cells to resist oxidative stress. The current article looks at the rationale behind the development of polycomponent mesopreparations, using NCTF as an example. Measurement feasability of advanced glycated end-products from skin samples after antioxidant vitamin supplementation in patients with type 2 diabetes. To determine the feasibility of measuring advanced glycated end-products AGEs from skin samples and to evaluate the effects of a combination of vitamins E and C on measures of glycemic control and AGEs in patients with type 2 diabetes mellitus.

Twenty-two patients with type 2 diabetes from a Family Medicine clinic were randomly assigned to receive a daily dietary supplement containing either a combination of mg of vitamin E and mg of vitamin C or matching placebo for a period of one year. AGEs were measured from skin samples taken from the buttock. Nineteen subjects completed this one-year pilot study.

There were no major problems found in measuring AGEs from skin samples taken from the butttock. Neither the treatment or placebo group had significant changes in glycemic control, protein glycosylation or AGEs. Skin samples taken from the buttock area may be an appropriate site for the determination of AGE levels as this procedure appeared to be well-tolerated. Daily vitamin E and C supplementation did not improve measures of glycemic control or AGE levels in this small sample of patients with type 2 diabetes. Because antioxidant vitamins are inexpensive and free of side effects, additional research using a variety of antioxidant vitamin combinations and dosing regimens is needed.

Incidence of skin cancers during 5-year follow-up after stopping antioxidant vitamins and mineral supplementation. In the SU. MAX study, antioxidant supplementation for 7. To investigate the potential residual or delayed effect of antioxidant supplementation on skin cancer incidence after a 5-year post-intervention follow-up.

Assessment of skin cancer including melanoma and non-melanoma during the post-intervention follow-up September August The SU. Total skin cancer incidence, including melanoma, squamous cell carcinoma and basal cell carcinoma. Six squamous cell carcinomas were found in women and 15 in men 10 and 25, respectively, for the total period. Finally, 40 basal cell carcinomas appeared in women and 36 in men 98 and 94, respectively, for the total period.

Regarding potential residual or delayed effects of supplementation in women, no increased risk of melanoma was observed during the post-intervention follow-up period. No delayed effects, either on melanoma or non-melanoma skin cancers, were observed for either gender. The risk of skin cancers associated with antioxidant intake declines following interruption of supplementation. This supports a causative role for antioxidants in the evolution of skin cancers. Nitroxides are more efficient inhibitors of oxidative damage to calf skin collagen than antioxidant vitamins.

Reactive oxygen species generated upon UV-A exposure appear to play a major role in dermal connective tissue transformations including degradation of skin collagen. Here we investigate on oxidative damage to collagen achieved by exposure to i UV-A irradiation and to ii AAPH-derived radicals and on its possible prevention using synthetic and natural antioxidants.

In both cases, dose-dependent protection was achieved by incubation with muM concentrations of nitroxide radicals, where the extent of protection was shown to be dictated by their structural differences whereas the vitamins E and C proved less efficient inhibitors of collagen damage.

These results suggest that nitroxide radicals may be able to prevent oxidative injury to dermal tissues in vivo alternatively to commonly used natural antioxidants. The active natural anti-oxidant properties of chamomile, milk thistle, and halophilic bacterial components in human skin in vitro. Studies have shown reactive oxygen species ROS type free radicals are linked to skin cancer and aging.

Therefore, it is important for us to identify agents that have anti-oxidant properties to protect skin against free radical damage. The purpose of this research is to investigate the anti-oxidant properties of bisabolol, silymarin, and ectoin that are components from chamomile, milk thistle, and halophilic bacteria, respectively. We measured the ability of bisabolol, silymarin, and ectoin to modulate the hydrogen peroxide H2O2 -induced upregulation of ROS free radicals in normal human skin fibroblasts in vitro.

Using a flow cytometry-based assay, we demonstrated that varying concentrations of these natural components were able to inhibit upregulation of H2O2-generated free radicals in human skin fibroblasts in vitro. Our results indicate components of chamomile, milk thistle, and halophilic bacteria exhibit anti-oxidant capabilities and warrant further study in clinical trials to characterize their anti-cancer and anti-aging capabilities. Skin is the outermost part of the body and is, thus, inevitably exposed to UV rays and environmental pollutants.

Oxidative stress by these hazardous factors accelerates skin aging and induces skin inflammation and carcinogenesis. Aryl hydrocarbon receptors AHRs are chemical sensors that are abundantly expressed in epidermal keratinocytes and mediate the production of reactive oxygen species.

To neutralize or minimize oxidative stress, the keratinocytes also express nuclear factor-erythroid 2-related factor-2 NRF2 , which is a master switch for antioxidant signaling. Notably, there is fine-tuned crosstalk between AHR and NRF2, which mutually increase or decrease their activation states. The precise mechanisms by which these phytochemicals differentially affect the AHR and NRF2 system remain largely unknown and warrant future investigation.

Background The objective of the present study was to determine the phytochemical content and the protective effect of red grape skin extract RGSE against fructose-mediated protein oxidation. Methods Antioxidant activity was measured by 2,2-diphenylpicrylhydrazyl DPPH , hydroxyl radical scavenging activity, superoxide radical scavenging activity, trolox equivalent antioxidant capacity, ferric reducing antioxidant power FRAP , ferrous ion chelating power.

The total phenols content was measured by Folin—Ciocalteu assay, the flavonoids content by the AlCl3 colorimetric method. Results The results showed that the content of total phenolics, flavonoids and total anthocyanins in RGSE was Photodynamic therapy improves the ultraviolet-irradiated hairless mice skin. Jorge, Ana Elisa S.

Chronic exposure to ultraviolet UV sunlight causes premature skin aging. In light of this fact, photodynamic therapy PDT is an emerging modality for treating cancer and other skin conditions, however its response on photoaged skin has not been fully illustrated by means of histopathology. For this reason, the aim of this study was analyze whether PDT can play a role on a mouse model of photoaging.

After the proper photosensitizer accumulation within the tissue, a non-coherent red nm light was performed and, after 14 days, skin samples were excised and processed for light microscopy, and their sections were stained with hematoxylin-eosin HE and Masson's Trichrome. These findings strongly indicate epidermal and dermal restoration, and consequently skin restoration.

In conclusion, this study provides suitable evidences that PDT improves the UV-irradiated hairless mice skin , supporting this technique as an efficient treatment for photoaged skin. Changes in element accumulation, phenolic metabolism, and antioxidative enzyme activities in the red- skin roots of Panax ginseng. Red- skin root disease has seriously decreased the quality and production of Panax ginseng ginseng.


The inorganic element composition, phenolic compound concentration, reactive oxidation system, antioxidant concentrations such as ascorbate and glutathione, activities of enzymes related to phenolic metabolism and oxidation, and antioxidative system particularly the ascorbate-glutathione cycle were examined using conventional methods.

Aluminum Al , iron Fe , magnesium, and phosphorus were increased, whereas manganese was unchanged and calcium was decreased in the epidermis and fibrous root of red- skin ginseng, which also contained higher levels of phenolic compounds, higher activities of the phenolic compound-synthesizing enzyme phenylalanine ammonia-lyase and the phenolic compound oxidation-related enzymes guaiacol peroxidase and polyphenoloxidase.

As the substrate of guaiacol peroxidase, higher levels of H 2 O 2 and correspondingly higher activities of superoxide dismutase and catalase were found in red- skin ginseng. Increased levels of ascorbate and glutathione; increased activities of l-galactose 1-dehydrogenase, ascorbate peroxidase, ascorbic acid oxidase, and glutathione reductase; and lower activities of dehydroascorbate reductase, monodehydroascorbate reductase, and glutathione peroxidase were found in red- skin ginseng.

Glutathione- S -transferase activity remained constant. Hence, higher element accumulation, particularly Al and Fe, activated multiple enzymes related to accumulation of phenolic compounds and their oxidation.

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