Imaging of the Human Brain in Health and Disease


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For the normal brain, ongoing experiments involve the evaluation of sensory, motor, visual, language, memory, and cognitive systems using functional MRI techniques.

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In addition, high-resolution anatomical imaging is being incorporated into a developing atlas of the human brain. Patient studies include the presurgical evaluation of patients with epilepsy, brain tumors, and vascular malformations.


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The evaluation of patients with neurodegenerative diseases and psychiatric disorders and the study of recovery of function after acute brain injury are active projects in this laboratory. The Positron Emission Tomography Laboratory has a high-resolution dedicated brain imaging PET device optimized for cerebral activation blood flow studies.

Human brain networks in health and disease.

Both normal and abnormal brain function are studied with PET. The study of human hemispheric specialization is an important research topic in the PET laboratory. Studies in normal subjects evaluate the relationship between handedness and cerebral dominance, behavioral-cerebral correlations and both inter- and intra-hemispheric participation in behavioral tasks.

Studies in patients include the exploration of the causes of a migraine headache, as well as the evaluation of acute and chronic neurological disorders. The data analysis laboratory contains extensive computer facilities for data analysis and visualization.


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The Transcranial Magnetic Stimulation TMS Laboratory has specialized equipment used to stimulate the brain directly using magnetic fields. The ultimate goal of Brain Mapping is to provide a means by which investigators and students can learn about brain function in health and disease through the integrated data sets collected and stored in digital brain libraries. By these methods, computer databases continually learn from the addition of new information to better characterize normal brain function and disease states, and provide a detailed circuitry of the brain's component parts.

Trainees at all levels participate in laboratory activities. They range from high school summer students to post-doctoral fellows. The Ahmanson-Lovelace Brain Mapping Building is a facility dedicated solely to the goals and missions of the program, unifying the expertise of many individuals and many methodologies under one roof.


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    Mapping the Human Brain in Health and Disease

    Since MRI does not use harmful radiation or radioactive tracers, patients can be scanned mutliple times in order to closely monitor the effects of new treatments. MRI scientists at the Djavad Mowafaghian Centre for Brain Health use MRI scanners as platforms for the development of apps for mapping the human brain in high detail and with high sensitivity to damage and potential repair.

    Damage to the myelin, for example due to multiple sclerosis, affects the functioning of the brain. Together with other advanced MRI techniques, these scans are used to find cures for multiple sclerosis, Parkinson disease, Alzheimer's disease or to improve treatment after neurotrauma.

    Imaging of the Human Brain in Health and Disease Imaging of the Human Brain in Health and Disease
    Imaging of the Human Brain in Health and Disease Imaging of the Human Brain in Health and Disease
    Imaging of the Human Brain in Health and Disease Imaging of the Human Brain in Health and Disease
    Imaging of the Human Brain in Health and Disease Imaging of the Human Brain in Health and Disease
    Imaging of the Human Brain in Health and Disease Imaging of the Human Brain in Health and Disease

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